diff --git a/pkg/dart2wasm/bin/run_wasm.js b/pkg/dart2wasm/bin/run_wasm.js
index c24cd1324b6..59049559d01 100644
--- a/pkg/dart2wasm/bin/run_wasm.js
+++ b/pkg/dart2wasm/bin/run_wasm.js
@@ -364,7 +364,11 @@ if (argsSplit != -1) {
   self.Response = function () { }
 
   self.location = {}
-  self.location.href = 'file://' + args[wasmArg];
+  if (args[wasmArg].startsWith('/')) {
+    self.location.href = 'file://' + args[wasmArg];
+  } else {
+    self.location.href = args[wasmArg];
+  }
 
   // Signals `Stopwatch._initTicker` to use `Date.now` to get ticks instead of
   // `performance.now`, as it's not available in d8.
diff --git a/tests/web/wasm/uri_base_test.dart b/tests/web/wasm/uri_base_test.dart
new file mode 100644
index 00000000000..74c4252e20a
--- /dev/null
+++ b/tests/web/wasm/uri_base_test.dart
@@ -0,0 +1,7 @@
+// Copyright (c) 2024, the Dart project authors.  Please see the AUTHORS file
+// for details. All rights reserved. Use of this source code is governed by a
+// BSD-style license that can be found in the LICENSE file.
+
+void main() {
+  print(Uri.base.toFilePath()); // should not crash
+}
diff --git a/tests/web/web.status b/tests/web/web.status
index 5a7a9407c0e..216bd2785f9 100644
--- a/tests/web/web.status
+++ b/tests/web/web.status
@@ -57,6 +57,7 @@ code_motion_exception_test: Skip # Required V8 specific format of JavaScript err
 [ $compiler == dart2wasm && $runtime != d8 ]
 wasm/source_map_simple_test: SkipByDesign # Reads source map file using d8's readbuffer
 wasm/source_map_simple_optimized_test: SkipByDesign # Reads source map file using d8's readbuffer
+wasm/uri_base_test: SkipByDesign # Converts Uri.base to file path
 
 [ $compiler == dartk && $runtime == vm ]
 new_from_env_test: SkipByDesign # dart2js only test