diff --git a/pkg/compiler/lib/src/inferrer/type_graph_inferrer.dart b/pkg/compiler/lib/src/inferrer/type_graph_inferrer.dart
index 68cf701ff14..418bd2d2372 100644
--- a/pkg/compiler/lib/src/inferrer/type_graph_inferrer.dart
+++ b/pkg/compiler/lib/src/inferrer/type_graph_inferrer.dart
@@ -1287,14 +1287,28 @@ class TypeGraphInferrerEngine
   }
 
   void clear() {
+    void cleanup(TypeInformation info) => info.cleanup();
+
+    allocatedCalls.forEach(cleanup);
     allocatedCalls.clear();
+
     defaultTypeOfParameter.clear();
-    types.typeInformations.values.forEach((info) => info.clear());
+
+    types.typeInformations.values.forEach(cleanup);
+
+    types.allocatedTypes.forEach(cleanup);
     types.allocatedTypes.clear();
+
     types.concreteTypes.clear();
+
+    types.allocatedClosures.forEach(cleanup);
     types.allocatedClosures.clear();
+
     analyzedElements.clear();
     generativeConstructorsExposingThis.clear();
+   
+    types.allocatedMaps.values.forEach(cleanup);
+    types.allocatedLists.values.forEach(cleanup);
   }
 
   Iterable<Element> getCallersOf(Element element) {
diff --git a/pkg/compiler/lib/src/inferrer/type_graph_nodes.dart b/pkg/compiler/lib/src/inferrer/type_graph_nodes.dart
index 98a9309d355..974e2d89d03 100644
--- a/pkg/compiler/lib/src/inferrer/type_graph_nodes.dart
+++ b/pkg/compiler/lib/src/inferrer/type_graph_nodes.dart
@@ -237,6 +237,12 @@ abstract class TypeInformation {
     abandonInferencing = false;
     doNotEnqueue = false;
   }
+
+  /// Destroys information not needed after type inference.
+  void cleanup() {
+    users = null;
+    _assignments = null;
+  }
 }
 
 abstract class ApplyableTypeInformation implements TypeInformation {
@@ -385,6 +391,10 @@ class MemberTypeInformation extends ElementTypeInformation
    */
   int closurizedCount = 0;
 
+  // Strict `bool` value is computed in cleanup(). Also used as a flag to see if
+  // cleanup has been called.
+  bool _isCalledOnce = null;
+
   /**
    * This map contains the callers of [element]. It stores all unique call sites
    * to enable counting the global number of call sites of [element].
@@ -392,18 +402,23 @@ class MemberTypeInformation extends ElementTypeInformation
    * A call site is either an AST [ast.Node], a [cps_ir.Node] or in the case of
    * synthesized calls, an [Element] (see uses of [synthesizeForwardingCall]
    * in [SimpleTypeInferrerVisitor]).
+   *
+   * The global information is summarized in [cleanup], after which [_callers]
+   * is set to `null`.
    */
-  final Map<Element, Setlet<Spannable>> _callers = new Map<Element, Setlet>();
+  Map<Element, Setlet<Spannable>> _callers;
 
   MemberTypeInformation._internal(Element element)
       : super._internal(null, element);
 
   void addCall(Element caller, Spannable node) {
     assert(node is ast.Node || node is cps_ir.Node || node is Element);
+    _callers ??= <Element, Setlet>{};
     _callers.putIfAbsent(caller, () => new Setlet()).add(node);
   }
 
   void removeCall(Element caller, node) {
+    if (_callers == null) return;
     Setlet calls = _callers[caller];
     if (calls == null) return;
     calls.remove(node);
@@ -412,9 +427,20 @@ class MemberTypeInformation extends ElementTypeInformation
     }
   }
 
-  Iterable<Element> get callers => _callers.keys;
+  Iterable<Element> get callers {
+    // TODO(sra): This is called only from an unused API. If it becomes used,
+    // [cleanup] will need to copy `_caller.keys`.
+    assert(false); // Unused.
+    return _callers.keys;
+  }
 
   bool isCalledOnce() {
+    assert(_isCalledOnce != null);
+    return _isCalledOnce;
+  }
+
+  bool _computeIsCalledOnce() {
+    if (_callers == null) return false;
     int count = 0;
     for (var set in _callers.values) {
       count += set.length;
@@ -530,6 +556,13 @@ class MemberTypeInformation extends ElementTypeInformation
 
     return super.hasStableType(inferrer);
   }
+
+  void cleanup() {
+    if (_isCalledOnce != null) return;
+    _isCalledOnce = _computeIsCalledOnce();
+    _callers = null;
+    super.cleanup();
+  }
 }
 
 /**
@@ -1319,6 +1352,12 @@ class ListTypeInformation extends TypeInformation
   }
 
   TypeMask safeType(TypeGraphInferrerEngine inferrer) => originalType;
+
+  void cleanup() {
+    super.cleanup();
+    elementType.cleanup();
+    _flowsInto = null;
+  }
 }
 
 /**
@@ -1482,6 +1521,16 @@ class MapTypeInformation extends TypeInformation
            super.hasStableType(inferrer);
   }
 
+  void cleanup() {
+    super.cleanup();
+    keyType.cleanup();
+    valueType.cleanup();
+    for (TypeInformation info in typeInfoMap.values) {
+      info.cleanup();
+    }
+    _flowsInto = null;
+  }
+
   String toString() {
     return 'Map $type (K:$keyType, V:$valueType) contents $typeInfoMap';
   }