diff --git a/pkg/dart2native/analysis_options.yaml b/pkg/dart2native/analysis_options.yaml
index d1e7e419769..8b452172bb4 100644
--- a/pkg/dart2native/analysis_options.yaml
+++ b/pkg/dart2native/analysis_options.yaml
@@ -8,3 +8,7 @@ linter:
   rules:
     - prefer_final_in_for_each
     - prefer_final_locals
+
+formatter:
+  trailing_commas: preserve
+
diff --git a/pkg/dart2native/lib/sdk.dart b/pkg/dart2native/lib/sdk.dart
index 73c510445be..fd478ced18b 100644
--- a/pkg/dart2native/lib/sdk.dart
+++ b/pkg/dart2native/lib/sdk.dart
@@ -38,10 +38,19 @@ class Sdk {
         'dartvm',
       );
 
-  String get dartAotRuntime => _executablePathFor(
-        'dartaotruntime',
-        forceProductInBuildRoot: true,
-      );
+  String dartAotRuntimeFor({
+    String? sanitizer,
+  }) {
+    final name = sanitizer != null && sanitizer != 'none'
+        ? 'dartaotruntime_$sanitizer'
+        : 'dartaotruntime';
+    return _executablePathFor(
+      name,
+      forceProductInBuildRoot: true,
+    );
+  }
+
+  String get dartAotRuntime => dartAotRuntimeFor();
 
   String get genSnapshot => _executablePathFor(
         'gen_snapshot',
diff --git a/pkg/dartdev/lib/src/commands/build.dart b/pkg/dartdev/lib/src/commands/build.dart
index e1cdd89656b..7abf7867521 100644
--- a/pkg/dartdev/lib/src/commands/build.dart
+++ b/pkg/dartdev/lib/src/commands/build.dart
@@ -139,14 +139,25 @@ then that is used instead.''',
         valueHelp: 'path',
         help: 'Path to output Ninja depfile',
       )
+      ..addOption(
+        'target-sanitizer',
+        help: 'Build with a specific target sanitizer.',
+        allowed: Sanitizer.available().map((s) => s.name).toList(),
+        defaultsTo: 'none',
+      )
       ..addExperimentalFlags(verbose: verbose);
   }
 
   @override
   Future<int> run() async {
+    final args = argResults!;
+    final sanitizer = Sanitizer.fromString(args.option('target-sanitizer'))!;
+    final targetDartAotRuntime = sdk.dartAotRuntimeFor(
+      sanitizer: sanitizer.name,
+    );
     if (!checkArtifactExists(sdk.genKernelSnapshot) ||
         !checkArtifactExists(sdk.genSnapshot) ||
-        !checkArtifactExists(sdk.dartAotRuntime) ||
+        !checkArtifactExists(targetDartAotRuntime) ||
         !checkArtifactExists(sdk.dart)) {
       return 255;
     }
@@ -156,7 +167,6 @@ then that is used instead.''',
       stderr.writeln("'dart build' is not supported on x86 architectures.");
       return 64;
     }
-    final args = argResults!;
 
     var target = args.option('target');
     if (target == null) {
@@ -205,6 +215,7 @@ then that is used instead.''',
       verbose: verbose,
       verbosity: verbosity,
       depFile: depFile,
+      sanitizer: sanitizer,
     );
   }
 
@@ -218,6 +229,7 @@ then that is used instead.''',
     required List<String> enabledExperiments,
     required bool verbose,
     required String verbosity,
+    Sanitizer sanitizer = Sanitizer.none,
     bool progressUpdatesOnStderr = false,
     String? depFile,
   }) async {
@@ -273,6 +285,8 @@ then that is used instead.''',
     pubspecUri ??= await DartNativeAssetsBuilder.findWorkspacePubspec(
       packageConfigUri,
     );
+    // TODO(https://github.com/dart-lang/native/issues/2497): Pass the sanitizer
+    // to the native assets builder.
     final builder = DartNativeAssetsBuilder(
       pubspecUri: pubspecUri,
       packageConfigUri: packageConfigUri,
@@ -315,13 +329,15 @@ then that is used instead.''',
         );
         final generator = KernelGenerator(
           genSnapshot: sdk.genSnapshot,
-          targetDartAotRuntime: sdk.dartAotRuntime,
+          targetDartAotRuntime: sdk.dartAotRuntimeFor(
+            sanitizer: sanitizer.name,
+          ),
           kind: Kind.exe,
           sourceFile: e.sourceEntryPoint.toFilePath(),
           outputFile: outputExeUri.toFilePath(),
           verbose: verbose,
           verbosity: verbosity,
-          defines: [],
+          defines: [...sanitizer.defines],
           packages: packageConfigUri.toFilePath(),
           targetOS: targetOS,
           enableExperiment: enabledExperiments.join(','),
@@ -395,6 +411,9 @@ Use linkMode as dynamic library instead.""",
 
         await snapshotGenerator.generate(
           nativeAssets: nativeAssetsYamlUri?.toFilePath(),
+          extraOptions: [
+            ...sanitizer.genSnapshotFlags,
+          ],
         );
 
         if (targetOS == OS.macOS) {
diff --git a/pkg/dartdev/lib/src/commands/compile.dart b/pkg/dartdev/lib/src/commands/compile.dart
index 89462588473..0414b08e854 100644
--- a/pkg/dartdev/lib/src/commands/compile.dart
+++ b/pkg/dartdev/lib/src/commands/compile.dart
@@ -70,6 +70,16 @@ enum Sanitizer {
     }
     return null;
   }
+
+  static List<Sanitizer> available() {
+    final v = Platform.version;
+    if (v.contains('"linux_x64"') || v.contains('"linux_arm64"')) {
+      return [none, asan, msan, tsan];
+    } else if (v.contains('"linux_riscv64"')) {
+      return [none, asan, tsan];
+    }
+    return [none];
+  }
 }
 
 bool checkFile(String sourcePath) {
@@ -608,14 +618,7 @@ Remove debugging information from the output and save it separately to the speci
     if (commandName != aotSnapshotCmdName) {
       return ['none'];
     }
-
-    final v = Platform.version;
-    if (v.contains('"linux_x64"') || v.contains('"linux_arm64"')) {
-      return ['none', 'asan', 'msan', 'tsan'];
-    } else if (v.contains('"linux_riscv64"')) {
-      return ['none', 'asan', 'tsan'];
-    }
-    return ['none'];
+    return Sanitizer.available().map((s) => s.name).toList();
   }
 
   @override
diff --git a/pkg/dartdev/test/native_assets/build_test.dart b/pkg/dartdev/test/native_assets/build_test.dart
index 6a81aeda89e..0e002644cfb 100644
--- a/pkg/dartdev/test/native_assets/build_test.dart
+++ b/pkg/dartdev/test/native_assets/build_test.dart
@@ -350,6 +350,39 @@ void main(List<String> args) {
       },
     );
   }
+
+  for (var sanitizer in ['asan', 'msan', 'tsan']) {
+    test('dart build cli --target-sanitizer $sanitizer', timeout: longTimeout,
+        () async {
+      await nativeAssetsTest('dart_app', (dartAppUri) async {
+        final result = await runDart(
+          arguments: [
+            'build',
+            'cli',
+            '--target-sanitizer',
+            sanitizer,
+          ],
+          workingDirectory: dartAppUri,
+          logger: logger,
+          expectExitCodeZero: false,
+        );
+        final Directory binDir = File(Platform.resolvedExecutable).parent;
+        final sanitizedRuntime =
+            File.fromUri(binDir.uri.resolve('dartaotruntime_$sanitizer'));
+        if (sanitizedRuntime.existsSync()) {
+          expect(result.exitCode, 0);
+          final relativeExeUri = relativeBundleUri
+              .resolve('bin/')
+              .resolve(OS.current.executableFileName('dart_app'));
+          final absoluteExeUri = dartAppUri.resolveUri(relativeExeUri);
+          expect(await File.fromUri(absoluteExeUri).exists(), true);
+        } else {
+          expect(result.stderr, contains('dartaotruntime_$sanitizer'));
+          expect(result.exitCode, 255);
+        }
+      });
+    }, skip: !Platform.isLinux);
+  }
 }
 
 Future<void> _withTempDir(Future<void> Function(Uri tempUri) fun) async {