diff --git a/runtime/vm/compiler/assembler/assembler_base.cc b/runtime/vm/compiler/assembler/assembler_base.cc
index bc9f9a6025c..50bdba70134 100644
--- a/runtime/vm/compiler/assembler/assembler_base.cc
+++ b/runtime/vm/compiler/assembler/assembler_base.cc
@@ -640,16 +640,14 @@ void AssemblerBase::Stop(const char* message) {
 uword ObjIndexPair::Hash(Key key) {
   switch (key.type()) {
     case ObjectPoolBuilderEntry::kImmediate128:
-      return key.imm128_.int_storage[0] ^ key.imm128_.int_storage[1] ^
-             key.imm128_.int_storage[2] ^ key.imm128_.int_storage[3];
-
+      return HashBytes(&key.imm128_, sizeof(key.imm128_));
 #if defined(TARGET_ARCH_IS_32_BIT)
     case ObjectPoolBuilderEntry::kImmediate64:
-      return key.imm64_;
+      return HashBytes(&key.imm64_, sizeof(key.imm64_));
 #endif
     case ObjectPoolBuilderEntry::kImmediate:
     case ObjectPoolBuilderEntry::kNativeFunction:
-      return key.imm_;
+      return HashBytes(&key.imm_, sizeof(key.imm_));
     case ObjectPoolBuilderEntry::kTaggedObject:
       return ObjectHash(*key.obj_);
   }
diff --git a/runtime/vm/hash.h b/runtime/vm/hash.h
index ad00e892d49..745a9bdaccb 100644
--- a/runtime/vm/hash.h
+++ b/runtime/vm/hash.h
@@ -28,14 +28,21 @@ inline uint32_t FinalizeHash(uint32_t hash, intptr_t hashbits = kBitsPerInt32) {
   return (hash == 0) ? 1 : hash;
 }
 
-inline uint32_t HashBytes(const uint8_t* bytes, intptr_t size) {
-  uint32_t hash = size;
-  while (size > 0) {
-    hash = CombineHashes(hash, *bytes);
-    bytes++;
-    size--;
+inline uint32_t HashBytes(const void* bytes,
+                          intptr_t len,
+                          intptr_t hashbits = kBitsPerInt32) {
+  if (len == 0) {
+    return 1;
   }
-  return hash;
+  uint32_t hash = len;
+  const intptr_t chunks = len / kInt32Size;
+  for (intptr_t i = 0; i < chunks; i++) {
+    hash = CombineHashes(hash, reinterpret_cast<const uint32_t*>(bytes)[i]);
+  }
+  for (intptr_t i = chunks * kInt32Size; i < len; i++) {
+    hash = CombineHashes(hash, reinterpret_cast<const uint8_t*>(bytes)[i]);
+  }
+  return FinalizeHash(hash, hashbits);
 }
 
 }  // namespace dart
diff --git a/runtime/vm/object.cc b/runtime/vm/object.cc
index 598eeaf4059..4fbd65cbf97 100644
--- a/runtime/vm/object.cc
+++ b/runtime/vm/object.cc
@@ -25978,13 +25978,14 @@ float Float32x4::w() const {
 }
 
 bool Float32x4::CanonicalizeEquals(const Instance& other) const {
+  NoSafepointScope no_safepoint;
   return memcmp(&untag()->value_, Float32x4::Cast(other).untag()->value_,
                 sizeof(simd128_value_t)) == 0;
 }
 
 uint32_t Float32x4::CanonicalizeHash() const {
-  return HashBytes(reinterpret_cast<const uint8_t*>(&untag()->value_),
-                   sizeof(simd128_value_t));
+  NoSafepointScope no_safepoint;
+  return HashBytes(&untag()->value_, sizeof(simd128_value_t), kHashBits);
 }
 
 const char* Float32x4::ToCString() const {
@@ -26062,13 +26063,14 @@ void Int32x4::set_value(simd128_value_t value) const {
 }
 
 bool Int32x4::CanonicalizeEquals(const Instance& other) const {
+  NoSafepointScope no_safepoint;
   return memcmp(&untag()->value_, Int32x4::Cast(other).untag()->value_,
                 sizeof(simd128_value_t)) == 0;
 }
 
 uint32_t Int32x4::CanonicalizeHash() const {
-  return HashBytes(reinterpret_cast<const uint8_t*>(&untag()->value_),
-                   sizeof(simd128_value_t));
+  NoSafepointScope no_safepoint;
+  return HashBytes(&untag()->value_, sizeof(simd128_value_t), kHashBits);
 }
 
 const char* Int32x4::ToCString() const {
@@ -26122,13 +26124,14 @@ void Float64x2::set_value(simd128_value_t value) const {
 }
 
 bool Float64x2::CanonicalizeEquals(const Instance& other) const {
+  NoSafepointScope no_safepoint;
   return memcmp(&untag()->value_, Float64x2::Cast(other).untag()->value_,
                 sizeof(simd128_value_t)) == 0;
 }
 
 uint32_t Float64x2::CanonicalizeHash() const {
-  return HashBytes(reinterpret_cast<const uint8_t*>(&untag()->value_),
-                   sizeof(simd128_value_t));
+  NoSafepointScope no_safepoint;
+  return HashBytes(&untag()->value_, sizeof(simd128_value_t), kHashBits);
 }
 
 const char* Float64x2::ToCString() const {
@@ -26181,19 +26184,8 @@ bool TypedData::CanonicalizeEquals(const Instance& other) const {
 }
 
 uint32_t TypedData::CanonicalizeHash() const {
-  const intptr_t len = this->LengthInBytes();
-  if (len == 0) {
-    return 1;
-  }
-  uint32_t hash = len;
-  const intptr_t chunks = len / kInt32Size;
-  for (intptr_t i = 0; i < chunks; i++) {
-    hash = CombineHashes(hash, GetUint32(i * kInt32Size));
-  }
-  for (intptr_t i = chunks * kInt32Size; i < len; i++) {
-    hash = CombineHashes(hash, GetUint8(i));
-  }
-  return FinalizeHash(hash, kHashBits);
+  NoSafepointScope no_safepoint;
+  return HashBytes(DataAddr(0), LengthInBytes(), kHashBits);
 }
 
 TypedDataPtr TypedData::New(intptr_t class_id,
diff --git a/runtime/vm/object.h b/runtime/vm/object.h
index b6775cc7f5b..ff7cdb6b696 100644
--- a/runtime/vm/object.h
+++ b/runtime/vm/object.h
@@ -5959,7 +5959,7 @@ class Instructions : public Object {
   uint32_t Hash() const { return Hash(ptr()); }
 
   static uint32_t Hash(const InstructionsPtr instr) {
-    return HashBytes(reinterpret_cast<const uint8_t*>(PayloadStart(instr)),
+    return HashBytes(reinterpret_cast<const void*>(PayloadStart(instr)),
                      Size(instr));
   }
 
diff --git a/runtime/vm/perfetto_utils.h b/runtime/vm/perfetto_utils.h
index c78c450f14c..9bc30e9655a 100644
--- a/runtime/vm/perfetto_utils.h
+++ b/runtime/vm/perfetto_utils.h
@@ -162,10 +162,7 @@ struct Span {
     return memcmp(data, other.data, length * sizeof(T)) == 0;
   }
 
-  uword Hash() const {
-    return HashBytes(reinterpret_cast<const uint8_t*>(data),
-                     length * sizeof(T));
-  }
+  uword Hash() const { return HashBytes(data, length * sizeof(T)); }
 };
 
 template <typename T, typename Allocator>
@@ -197,7 +194,7 @@ struct Interned {
     if constexpr (DefinesHashAndEquality<T>) {
       return data.Hash();
     } else {
-      return HashBytes(reinterpret_cast<const uint8_t*>(&data), sizeof(T));
+      return HashBytes(&data, sizeof(T));
     }
   }