diff --git a/runtime/lib/isolate.cc b/runtime/lib/isolate.cc
index a908fedb8a3..907828da43c 100644
--- a/runtime/lib/isolate.cc
+++ b/runtime/lib/isolate.cc
@@ -885,7 +885,6 @@ class SpawnIsolateTask : public ThreadPool::Task {
       auto thread = Thread::Current();
       TransitionNativeToVM transition(thread);
       StackZone zone(thread);
-      HandleScope hs(thread);
 
       success = EnqueueEntrypointInvocationAndNotifySpawner(thread);
 
diff --git a/runtime/vm/compiler/backend/il.cc b/runtime/vm/compiler/backend/il.cc
index e630c400f21..b12dbdd23ec 100644
--- a/runtime/vm/compiler/backend/il.cc
+++ b/runtime/vm/compiler/backend/il.cc
@@ -171,7 +171,6 @@ class CidCheckerForRanges : public ValueObject {
     subtype_ = to_check_.RareType();
     // Create local zone because deep hierarchies may allocate lots of handles.
     StackZone stack_zone(thread_);
-    HANDLESCOPE(thread_);
     return subtype_.IsSubtypeOf(supertype_, Heap::kNew);
   }
 
diff --git a/runtime/vm/compiler/jit/compiler.cc b/runtime/vm/compiler/jit/compiler.cc
index 14b98c6a5b5..35e40f50f2e 100644
--- a/runtime/vm/compiler/jit/compiler.cc
+++ b/runtime/vm/compiler/jit/compiler.cc
@@ -1015,7 +1015,6 @@ void BackgroundCompiler::Run() {
     Thread* thread = Thread::Current();
     StackZone stack_zone(thread);
     Zone* zone = stack_zone.GetZone();
-    HANDLESCOPE(thread);
     Function& function = Function::Handle(zone);
     QueueElement* element = nullptr;
     {
diff --git a/runtime/vm/dart.cc b/runtime/vm/dart.cc
index 01498aa6216..e32f9a0fb63 100644
--- a/runtime/vm/dart.cc
+++ b/runtime/vm/dart.cc
@@ -406,7 +406,6 @@ char* Dart::DartInit(const Dart_InitializeParams* params) {
     Thread* T = Thread::Current();
     ASSERT(T != nullptr);
     StackZone zone(T);
-    HandleScope handle_scope(T);
     Object::InitNullAndBool(vm_isolate_->group());
     vm_isolate_->isolate_group_->set_object_store(new ObjectStore());
     vm_isolate_->isolate_object_store()->Init();
diff --git a/runtime/vm/dart_api_impl.cc b/runtime/vm/dart_api_impl.cc
index fec5d63f9ce..55dca4bfd3f 100644
--- a/runtime/vm/dart_api_impl.cc
+++ b/runtime/vm/dart_api_impl.cc
@@ -1208,7 +1208,6 @@ static Dart_Isolate CreateIsolate(IsolateGroup* group,
   bool success = false;
   {
     StackZone zone(T);
-    HandleScope handle_scope(T);
 
 #if defined(SUPPORT_TIMELINE)
     TimelineBeginEndScope tbes(T, Timeline::GetIsolateStream(),
@@ -1408,7 +1407,6 @@ DART_EXPORT void Dart_ShutdownIsolate() {
 
   {
     StackZone zone(T);
-    HandleScope handle_scope(T);
     Dart::RunShutdownCallback();
   }
   Dart::ShutdownIsolate(T);
diff --git a/runtime/vm/ffi_callback_metadata_test.cc b/runtime/vm/ffi_callback_metadata_test.cc
index 982e65d7063..c2c5ad7b0b9 100644
--- a/runtime/vm/ffi_callback_metadata_test.cc
+++ b/runtime/vm/ffi_callback_metadata_test.cc
@@ -87,7 +87,6 @@ VM_UNIT_TEST_CASE(FfiCallbackMetadata_CreateSyncFfiCallback) {
     ASSERT(isolate == isolate_scope.isolate());
     TransitionNativeToVM transition(thread);
     StackZone stack_zone(thread);
-    HandleScope handle_scope(thread);
 
     auto* zone = thread->zone();
 
@@ -182,7 +181,6 @@ VM_UNIT_TEST_CASE(FfiCallbackMetadata_CreateAsyncFfiCallback) {
     ASSERT(thread->isolate() == isolate_scope.isolate());
     TransitionNativeToVM transition(thread);
     StackZone stack_zone(thread);
-    HandleScope handle_scope(thread);
 
     auto* zone = thread->zone();
 
@@ -279,7 +277,6 @@ VM_UNIT_TEST_CASE(FfiCallbackMetadata_CreateIsolateLocalFfiCallback) {
     ASSERT(thread->isolate() == isolate_scope.isolate());
     TransitionNativeToVM transition(thread);
     StackZone stack_zone(thread);
-    HandleScope handle_scope(thread);
 
     auto* zone = thread->zone();
 
@@ -439,7 +436,6 @@ VM_UNIT_TEST_CASE(FfiCallbackMetadata_DeleteTrampolines) {
   ASSERT(isolate == isolate_scope.isolate());
   TransitionNativeToVM transition(thread);
   StackZone stack_zone(thread);
-  HandleScope handle_scope(thread);
 
   auto* fcm = FfiCallbackMetadata::Instance();
   std::unordered_set<FfiCallbackMetadata::Trampoline> tramps;
@@ -513,7 +509,6 @@ static void RunBigRandomMultithreadedTest(uint64_t seed) {
   ASSERT(isolate == isolate_scope.isolate());
   TransitionNativeToVM transition(thread);
   StackZone stack_zone(thread);
-  HandleScope handle_scope(thread);
 
   struct TrampolineWithPort {
     FfiCallbackMetadata::Trampoline tramp;
diff --git a/runtime/vm/isolate.cc b/runtime/vm/isolate.cc
index 0d3532d7934..d49bce7dfe3 100644
--- a/runtime/vm/isolate.cc
+++ b/runtime/vm/isolate.cc
@@ -1446,7 +1446,6 @@ MessageHandler::MessageStatus IsolateMessageHandler::HandleMessage(
   Thread* thread = Thread::Current();
   StackZone stack_zone(thread);
   Zone* zone = stack_zone.GetZone();
-  HandleScope handle_scope(thread);
 #if defined(SUPPORT_TIMELINE)
   TimelineBeginEndScope tbes(
       thread, Timeline::GetIsolateStream(),
@@ -1575,7 +1574,6 @@ void IsolateMessageHandler::NotifyPauseOnStart() {
   if (Service::debug_stream.enabled() || FLAG_warn_on_pause_with_no_debugger) {
     StartIsolateScope start_isolate(I);
     StackZone zone(T);
-    HandleScope handle_scope(T);
     ServiceEvent pause_event(I, ServiceEvent::kPauseStart);
     Service::HandleEvent(&pause_event);
   } else if (FLAG_trace_service) {
@@ -1591,7 +1589,6 @@ void IsolateMessageHandler::NotifyPauseOnExit() {
   if (Service::debug_stream.enabled() || FLAG_warn_on_pause_with_no_debugger) {
     StartIsolateScope start_isolate(I);
     StackZone zone(T);
-    HandleScope handle_scope(T);
     ServiceEvent pause_event(I, ServiceEvent::kPauseExit);
     Service::HandleEvent(&pause_event);
   } else if (FLAG_trace_service) {
@@ -2478,7 +2475,6 @@ void Isolate::RunAndCleanupFinalizersOnShutdown() {
   // but we no longer allocate new heap objects.
   Thread* thread = Thread::Current();
   StackZone stack_zone(thread);
-  HandleScope handle_scope(thread);
   NoSafepointScope no_safepoint_scope;
 
   // Set live finalizers isolate to null, before deleting the message handler.
@@ -2526,7 +2522,6 @@ void Isolate::LowLevelShutdown() {
   // but we no longer allocate new heap objects.
   Thread* thread = Thread::Current();
   StackZone stack_zone(thread);
-  HandleScope handle_scope(thread);
   NoSafepointScope no_safepoint_scope;
 
   // Notify exit listeners that this isolate is shutting down.
@@ -2612,7 +2607,6 @@ void Isolate::Shutdown() {
     StackZone zone(thread);
     ServiceIsolate::SendIsolateShutdownMessage();
 #if !defined(PRODUCT)
-    HandleScope handle_scope(thread);
     debugger()->Shutdown();
 #endif
 
diff --git a/runtime/vm/kernel_isolate.cc b/runtime/vm/kernel_isolate.cc
index 0468d8a81a3..ecf7983d286 100644
--- a/runtime/vm/kernel_isolate.cc
+++ b/runtime/vm/kernel_isolate.cc
@@ -125,7 +125,6 @@ class RunKernelTask : public ThreadPool::Task {
       auto T = Thread::Current();
       TransitionNativeToVM transition(T);
       StackZone zone(T);
-      HandleScope handle_scope(T);
 
       auto I = T->isolate();
       ASSERT(I->is_kernel_isolate());
diff --git a/runtime/vm/service_isolate.cc b/runtime/vm/service_isolate.cc
index 03924ebf65c..4a9181e1452 100644
--- a/runtime/vm/service_isolate.cc
+++ b/runtime/vm/service_isolate.cc
@@ -419,7 +419,6 @@ class RunServiceTask : public ThreadPool::Task {
       auto T = Thread::Current();
       TransitionNativeToVM transition(T);
       StackZone zone(T);
-      HandleScope handle_scope(T);
 
       auto I = T->isolate();
       ASSERT(I->is_service_isolate());
diff --git a/runtime/vm/snapshot_test.cc b/runtime/vm/snapshot_test.cc
index f6090633d73..8e481092f3c 100644
--- a/runtime/vm/snapshot_test.cc
+++ b/runtime/vm/snapshot_test.cc
@@ -752,7 +752,6 @@ VM_UNIT_TEST_CASE(FullSnapshot) {
     Thread* thread = Thread::Current();
     TransitionNativeToVM transition(thread);
     StackZone zone(thread);
-    HandleScope scope(thread);
 
     Dart_Handle result = Api::CheckAndFinalizePendingClasses(thread);
     {
@@ -1010,7 +1009,6 @@ VM_UNIT_TEST_CASE(DartGeneratedListMessages) {
   {
     CHECK_API_SCOPE(thread);
     TransitionNativeToVM transition(thread);
-    HANDLESCOPE(thread);
     StackZone zone(thread);
     {
       // Generate a list of nulls from Dart code.
@@ -1134,7 +1132,6 @@ VM_UNIT_TEST_CASE(DartGeneratedArrayLiteralMessages) {
   {
     CHECK_API_SCOPE(thread);
     TransitionNativeToVM transition(thread);
-    HANDLESCOPE(thread);
     StackZone zone(thread);
     {
       // Generate a list of nulls from Dart code.
@@ -1367,7 +1364,6 @@ VM_UNIT_TEST_CASE(DartGeneratedListMessagesWithBackref) {
   {
     CHECK_API_SCOPE(thread);
     TransitionNativeToVM transition(thread);
-    HANDLESCOPE(thread);
     StackZone zone(thread);
     {
       // Generate a list of strings from Dart code.
@@ -1566,7 +1562,6 @@ VM_UNIT_TEST_CASE(DartGeneratedArrayLiteralMessagesWithBackref) {
   {
     CHECK_API_SCOPE(thread);
     TransitionNativeToVM transition(thread);
-    HANDLESCOPE(thread);
     StackZone zone(thread);
     {
       // Generate a list of strings from Dart code.
@@ -1807,7 +1802,6 @@ VM_UNIT_TEST_CASE(DartGeneratedListMessagesWithTypedData) {
   {
     CHECK_API_SCOPE(thread);
     TransitionNativeToVM transition(thread);
-    HANDLESCOPE(thread);
     StackZone zone(thread);
     {
       // Generate a list of Uint8Lists from Dart code.
diff --git a/runtime/vm/thread.cc b/runtime/vm/thread.cc
index d91af35fdb8..3937401aa5e 100644
--- a/runtime/vm/thread.cc
+++ b/runtime/vm/thread.cc
@@ -583,7 +583,6 @@ void Thread::EnterIsolateGroupAsMutator(IsolateGroup* isolate_group,
   thread->AssertDartMutatorInvariants();
 
   StackZone zone(thread);
-  HANDLESCOPE(thread);
   if (isolate_group->object_store()->tag_table() !=
       GrowableObjectArray::null()) {
     // Set up default UserTag.
diff --git a/runtime/vm/timeline.cc b/runtime/vm/timeline.cc
index 20c5757ac77..822b2558f55 100644
--- a/runtime/vm/timeline.cc
+++ b/runtime/vm/timeline.cc
@@ -2703,7 +2703,6 @@ void Timeline::DrainCompletedSampleBlocksIntoRecorder(
 
   DisableThreadInterruptsScope dtis(thread);
   StackZone zone(thread);
-  HandleScope handle_scope(thread);
   Profile profile;
   NoAllocationSampleFilter filter(isolate->main_port(), Thread::kMutatorTask,
                                   streaming_start_micros,
diff --git a/runtime/vm/unit_test.h b/runtime/vm/unit_test.h
index 1d1942b8ca9..cc6d47603e4 100644
--- a/runtime/vm/unit_test.h
+++ b/runtime/vm/unit_test.h
@@ -56,7 +56,6 @@
     ASSERT(__thread__->isolate() == __test_isolate__.isolate());               \
     TransitionNativeToVM transition(__thread__);                               \
     StackZone __zone__(__thread__);                                            \
-    HandleScope __hs__(__thread__);                                            \
     Dart_TestHelper##name(__thread__);                                         \
   }                                                                            \
   static void Dart_TestHelper##name(Thread* thread)
@@ -76,7 +75,6 @@
     ASSERT(__thread__->isolate() == __test_isolate__.isolate());               \
     TransitionNativeToVM transition1(__thread__);                              \
     StackZone __zone__(__thread__);                                            \
-    HandleScope __hs__(__thread__);                                            \
     TransitionVMToNative transition2(__thread__);                              \
     Dart_TestHelper##name(__thread__);                                         \
   }                                                                            \