diff --git a/runtime/vm/profiler.cc b/runtime/vm/profiler.cc
index 29eb1e1d768..8226d93da8a 100644
--- a/runtime/vm/profiler.cc
+++ b/runtime/vm/profiler.cc
@@ -37,7 +37,7 @@ DEFINE_FLAG(bool, trace_profiled_isolates, false, "Trace profiled isolates.");
 #endif
 DEFINE_FLAG(int, profile_depth, 8,
             "Maximum number stack frames walked. Minimum 1. Maximum 255.");
-#if defined(PROFILE_NATIVE_CODE) || defined(USING_SIMULATOR)
+#if defined(USING_SIMULATOR)
 DEFINE_FLAG(bool, profile_vm, true,
             "Always collect native stack traces.");
 #else
diff --git a/tools/gyp/configurations_android.gypi b/tools/gyp/configurations_android.gypi
index c60d776d577..80ff1c66b27 100644
--- a/tools/gyp/configurations_android.gypi
+++ b/tools/gyp/configurations_android.gypi
@@ -57,7 +57,7 @@
               '-fno-omit-frame-pointer',
             ],
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
@@ -82,7 +82,7 @@
               '-fno-omit-frame-pointer',
             ],
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
diff --git a/tools/gyp/configurations_make.gypi b/tools/gyp/configurations_make.gypi
index 1556f16f7dd..15eee37a9a4 100644
--- a/tools/gyp/configurations_make.gypi
+++ b/tools/gyp/configurations_make.gypi
@@ -200,7 +200,7 @@
               '-fno-omit-frame-pointer',
             ],
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
@@ -217,7 +217,7 @@
               '-fno-omit-frame-pointer',
             ],
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
diff --git a/tools/gyp/configurations_msvs.gypi b/tools/gyp/configurations_msvs.gypi
index 46604eb1ca6..3c859ce89e1 100644
--- a/tools/gyp/configurations_msvs.gypi
+++ b/tools/gyp/configurations_msvs.gypi
@@ -63,7 +63,7 @@
               },
             },
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
@@ -107,7 +107,7 @@
               },
             },
             'defines': [
-              'PROFILE_NATIVE_CODE'
+              'NATIVE_CODE_HAS_FRAME_POINTERS'
             ],
           }],
         ],
diff --git a/tools/gyp/configurations_xcode.gypi b/tools/gyp/configurations_xcode.gypi
index 6bd04527e34..3f22df5ec59 100644
--- a/tools/gyp/configurations_xcode.gypi
+++ b/tools/gyp/configurations_xcode.gypi
@@ -63,7 +63,7 @@
               ],
             },
             'defines': [
-              'PROFILE_NATIVE_CODE',
+              'NATIVE_CODE_HAS_FRAME_POINTERS',
             ],
           }],
         ],