diff --git a/runtime/vm/runtime_entry.h b/runtime/vm/runtime_entry.h
index 1b35e0ebde8..bede33e6ce6 100644
--- a/runtime/vm/runtime_entry.h
+++ b/runtime/vm/runtime_entry.h
@@ -85,6 +85,15 @@ class RuntimeEntry : public BaseRuntimeEntry {
   } while (0)
 #endif
 
+#if defined(USING_SIMULATOR)
+#define CHECK_SIMULATOR_STACK_OVERFLOW()                                       \
+  if (!OSThread::Current()->HasStackHeadroom()) {                              \
+    Exceptions::ThrowStackOverflow();                                          \
+  }
+#else
+#define CHECK_SIMULATOR_STACK_OVERFLOW()
+#endif  // defined(USING_SIMULATOR)
+
 // Helper macros for declaring and defining runtime entries.
 
 #define DEFINE_RUNTIME_ENTRY(name, argument_count)                             \
@@ -106,6 +115,7 @@ class RuntimeEntry : public BaseRuntimeEntry {
       TransitionGeneratedToVM transition(thread);                              \
       StackZone zone(thread);                                                  \
       HANDLESCOPE(thread);                                                     \
+      CHECK_SIMULATOR_STACK_OVERFLOW();                                        \
       DRT_Helper##name(isolate, thread, zone.GetZone(), arguments);            \
     }                                                                          \
   }                                                                            \